Norma A. Cortez-Lemus and Angel Licea-Claveríe*
Tecnológico Nacional de México/Instituto Tecnológico de Tijuana, Centro de Graduados e Investigación en Química, A.P. 1166, C.P. 22000 Tijuana, B.C., México.
Keynote: "Preparation of Star-Polymers by RAFT-polymerization and their Application as Controlled Drug Delivery Vehicles”
Reversible addition-fragmentation chain transfer (RAFT) polymerization is nowadays a well-established polymerization technique for the preparation of a multitude of polymers controlling their molecular weight, molecular weight distribution, end-group functionalization, architecture and topology. The preparation of blockcopolymers by RAFT is one of the main applications developed. In this contribution the application of RAFT polymerization for the preparation of star-polymers in our group will be reviewed with two important characteristics: the polymers are environment responsive polymers (thermal- or pH-responsive) and the resulting star polymers are candidates for entrapping and controlled release of drugs. Two strategies for the synthesis are going to be presented:
1.-Star polymers with crosslinked core and not well-controlled number of arms; and
2.-Star polymers with well-defined number of arms but simple core.